Server : Apache/2.4.6 (CentOS) OpenSSL/1.0.2k-fips PHP/7.4.20 System : Linux st2.domain.com 3.10.0-1127.10.1.el7.x86_64 #1 SMP Wed Jun 3 14:28:03 UTC 2020 x86_64 User : apache ( 48) PHP Version : 7.4.20 Disable Function : NONE Directory : /var/www/html/vidoe.top/upload/subtitle/03-2019/ |
WEBVTT - https://subtitletools.com 00:00:28.094 --> 00:00:30.063 - Excuse me, Dr. King? - I'm sorry. 00:00:30.064 --> 00:00:32.399 I don't have any more time. I'm already late for my plane. 00:00:32.400 --> 00:00:34.867 My name's Annie Parker. 00:00:37.837 --> 00:00:39.773 Oh. 00:00:40.675 --> 00:00:43.143 I read your letters. 00:00:43.144 --> 00:00:45.612 I heard you were in town. 00:00:45.613 --> 00:00:49.149 I tried to catch your lecture, but... the traffic was horrible. 00:00:49.150 --> 00:00:51.117 - I'm sorry. - It's okay. 00:00:51.118 --> 00:00:54.787 It was a bit dry. My jokes didn't play very well. 00:00:57.123 --> 00:01:00.226 - That's a pretty necklace. - Thank you. 00:01:00.227 --> 00:01:04.696 It was my mom's. I had it restrung recently. 00:01:04.831 --> 00:01:06.333 - You know, she... - Hey, I'm sorry. 00:01:06.334 --> 00:01:11.804 I really do have to go. I hope we can speak again. All the best. 00:01:31.057 --> 00:01:36.628 Oh, you might feel some discomfort. Just relax. 00:01:47.607 --> 00:01:50.910 There are great mysteries out there. 00:01:50.911 --> 00:01:54.080 Strange and magical, 00:01:54.081 --> 00:01:56.782 hidden in codes. 00:01:58.952 --> 00:02:00.920 Did you ever wonder... 00:02:00.921 --> 00:02:05.525 if you knew those codes, could you change your future? 00:02:23.143 --> 00:02:25.779 - Slap. - Snap. 00:02:25.780 --> 00:02:30.617 That's my big sister Joan and I. She knew things. 00:02:30.618 --> 00:02:34.020 That's where Death hides when he comes to the house. 00:02:34.021 --> 00:02:36.122 He sleeps most of the time. 00:02:36.123 --> 00:02:40.726 But you should be very quiet when you're up here so you don't wake him up. 00:02:42.729 --> 00:02:45.265 Did Mommy wake him up? 00:02:45.266 --> 00:02:48.367 Yes, she did. 00:02:51.971 --> 00:02:56.208 She blew it, and now we don't have a mommy anymore. 00:02:59.546 --> 00:03:02.349 And he'll get us too if we're not careful, 00:03:02.350 --> 00:03:05.883 like he did Grandma and Aunt Lil. 00:03:07.654 --> 00:03:11.291 - Snap. - Snap. 00:03:11.292 --> 00:03:13.926 And this is my story. 00:03:23.403 --> 00:03:27.440 Some girls love to run around 00:03:27.441 --> 00:03:31.277 Like to handle everything they see 00:03:31.278 --> 00:03:35.081 But my girl has more fun around 00:03:35.082 --> 00:03:38.518 And you know she'd rather be with me 00:03:38.519 --> 00:03:40.220 Me-oh my 00:03:40.221 --> 00:03:44.124 Lucky guy is what I am 00:03:44.125 --> 00:03:48.061 Tell you why you'll understand 00:03:48.062 --> 00:03:53.231 She don't fly although she can 00:03:54.467 --> 00:03:58.171 Some boys like to run around 00:03:58.172 --> 00:04:02.008 They don't think about the things they do 00:04:02.009 --> 00:04:05.778 But this boy wants to settle down 00:04:05.779 --> 00:04:09.549 And you know he'd rather be with you 00:04:09.550 --> 00:04:14.319 Me-oh my, lucky guy is what I am... 00:04:14.320 --> 00:04:17.657 That's me, not as confident as I should be, 00:04:17.658 --> 00:04:21.427 so I would make up for it by making bad choices. 00:04:21.428 --> 00:04:24.796 That's my sister Joan all grown up. 00:04:25.665 --> 00:04:29.502 And that's Joan's best friend Louise, who my dad said was trouble with a capital T, 00:04:29.503 --> 00:04:32.939 which made Joan, who was always good, like her even more. 00:04:32.940 --> 00:04:35.408 That's Paul, who was sweet and funny. 00:04:35.409 --> 00:04:39.212 We fell in love and got engaged when I was only 18... 00:04:39.213 --> 00:04:42.182 always a good idea... and later got married 00:04:42.183 --> 00:04:44.817 because he was sweet but also because he had a great ass 00:04:44.818 --> 00:04:47.187 which was like a piece of pneumatic machinery. 00:04:47.188 --> 00:04:51.891 Thumpity thumpity thumpity thump. Thumpity thumpity thump. 00:04:51.892 --> 00:04:54.427 He was going to be a musician, which is hard, 00:04:54.428 --> 00:04:58.364 so until then, he was working as a pool cleaner... 00:04:58.365 --> 00:05:00.733 in Toronto. 00:05:01.335 --> 00:05:04.237 My dad died suddenly in 1972. 00:05:04.238 --> 00:05:07.507 I guess that's where we should start. 00:05:08.209 --> 00:05:13.011 Give heed, O Lord, to my prayer, the sound of my voice. 00:05:15.715 --> 00:05:19.451 - You ready to go? - I need another minute. 00:05:27.193 --> 00:05:29.928 - I'm gonna stay here. - Okay. 00:05:33.032 --> 00:05:35.768 People behave oddly around the bereaved. 00:05:35.769 --> 00:05:36.903 Hey. 00:05:36.904 --> 00:05:38.905 They can't help themselves. 00:05:38.906 --> 00:05:42.041 - I'm sorry. - That's okay. 00:05:42.443 --> 00:05:47.913 - You're, like, one of the main mourners? - Excuse me? 00:05:48.415 --> 00:05:51.450 I don't mean in a bad way. 00:05:54.855 --> 00:05:57.022 So... 00:05:57.524 --> 00:06:01.192 what are you doing after this? 00:06:02.428 --> 00:06:05.098 After this is the wake. 00:06:05.099 --> 00:06:07.399 Right. 00:06:07.501 --> 00:06:10.469 But after that? 00:06:19.812 --> 00:06:22.148 So you think your mother suffered? 00:06:22.149 --> 00:06:25.418 My wife went through 18 months of agony. 00:06:25.419 --> 00:06:30.657 To lose your mother and your father. I can't imagine how lonely that must be. 00:06:30.658 --> 00:06:34.094 Every day it was worse. That's suffering. 00:06:34.095 --> 00:06:39.032 Just to be by yourself. It must be so painful, 00:06:39.033 --> 00:06:42.268 so lonely. 00:06:43.170 --> 00:06:48.406 She was wrong, of course. My parents were gone, but I had my sister, Joan. 00:06:49.809 --> 00:06:52.977 And we didn't know what trouble we were in. 00:06:55.081 --> 00:06:58.651 So I have to ask, Dr. King. What's the story with the clock there? 00:06:58.652 --> 00:07:00.386 The clock is marked at every 12 minutes. 00:07:00.387 --> 00:07:03.556 That's how often a woman will die of breast cancer in this country. 00:07:03.557 --> 00:07:05.658 - Well, that's... - One in nine. 00:07:05.659 --> 00:07:07.994 Two million over the next 20 years. 00:07:07.995 --> 00:07:12.365 - Potentially, but... - Maybe your wife. Your daughter. 00:07:12.366 --> 00:07:15.369 I think what Dr. King means... 00:07:15.370 --> 00:07:19.238 is that the disease, along with a potential cure, 00:07:19.239 --> 00:07:22.809 is of interest to a vast number of people... a cross section... 00:07:22.810 --> 00:07:26.012 I'm sorry, Allen. I just... I wanna be clear about this, Dr. King. 00:07:26.013 --> 00:07:30.917 You believe that there may be a genetic link to some breast cancers? 00:07:30.918 --> 00:07:32.685 I do. 00:07:32.686 --> 00:07:35.722 Even though virtually no one else believes this to be true? 00:07:35.723 --> 00:07:37.957 That's correct. 00:07:38.459 --> 00:07:41.661 And to prove your theory, you're going to have to examine the... 00:07:41.662 --> 00:07:44.063 - The human genome. - The human genome, which has... 00:07:44.064 --> 00:07:48.599 - 100,000 genes. - Or so, give or take a few. 00:07:51.204 --> 00:07:54.340 And how many women are in your study? 00:07:54.341 --> 00:07:58.111 - We began with several thousand. - Not so many. 00:07:58.112 --> 00:08:00.547 And you'd have to interview them all, yes? 00:08:00.548 --> 00:08:04.182 Most. Uh-huh. Yes. 00:08:05.818 --> 00:08:10.322 100,000 genes, several thousand women, 00:08:10.323 --> 00:08:12.025 and no certain outcome? 00:08:12.026 --> 00:08:14.394 Of course, we're already well into our research. 00:08:14.395 --> 00:08:18.730 - Oh, well, how far along are you? - Um... 00:08:22.735 --> 00:08:29.642 So, 74... No, no. Um... 00:08:29.643 --> 00:08:33.145 - six more. - Uh-huh. 00:08:33.747 --> 00:08:36.314 So, 80... 00:08:38.885 --> 00:08:41.653 Um... 00:08:46.292 --> 00:08:50.297 Right. Well, thank you. Thank you so much for your time and your hospitality. 00:08:50.298 --> 00:08:53.466 We'll... we'll be in touch. And we're obviously very interested 00:08:53.467 --> 00:08:57.068 in helping you with something so important, so... 00:09:05.344 --> 00:09:08.681 - I can't see it, Allen. I'm sorry. - Can't see it? 00:09:08.682 --> 00:09:10.550 We're looking at something like 20 years here. 00:09:10.551 --> 00:09:12.986 - Yeah, but Dr. King thinks... - Dr. King thinks. 00:09:12.987 --> 00:09:15.788 She thinks. Nobody else thinks. 00:09:15.789 --> 00:09:17.857 What is it about people like Mary-Claire King 00:09:17.858 --> 00:09:20.393 that think the world owes them a living, huh? 00:09:20.394 --> 00:09:24.263 She's like that grasshopper with his little violin. 00:09:24.264 --> 00:09:25.565 - Pardon? - Grasshopper. 00:09:25.566 --> 00:09:30.436 You know, he plays his little violin. He says, "The world owes me a living." 00:09:30.437 --> 00:09:33.473 Give him a PhD, there's your doctor friend right there. 00:09:33.474 --> 00:09:39.145 You're comparing one of our most brilliant geneticists to a cartoon grasshopper? 00:09:39.146 --> 00:09:44.016 The answer's no, Allen. So let's leave it alone, huh? 00:09:44.017 --> 00:09:46.019 Sorry. 00:09:47.421 --> 00:09:49.589 He didn't like me, did he? 00:09:49.590 --> 00:09:52.158 He... No. 00:09:52.159 --> 00:09:55.761 - I'm sure that... - What did he say? 00:09:55.762 --> 00:09:59.932 He compared you to an animated grasshopper. 00:09:59.933 --> 00:10:03.001 Did he? Goodness. 00:10:03.403 --> 00:10:06.505 Well, that's sort of charming in a way. 00:10:06.907 --> 00:10:09.408 - Did you tell him about the... - No, I... 00:10:09.409 --> 00:10:12.044 - He wasn't having any of it. - We could... 00:10:12.045 --> 00:10:14.546 Okay. I see. 00:10:15.048 --> 00:10:18.250 So, thank you... 00:10:18.752 --> 00:10:21.553 for coming out. 00:10:25.591 --> 00:10:29.562 - What will you do? - What will I do? My work. 00:10:29.563 --> 00:10:32.297 I'll do my work. 00:10:35.668 --> 00:10:40.907 I do I think about you day and night 00:10:40.908 --> 00:10:45.378 It's only right to think about the girl you love 00:10:45.379 --> 00:10:52.418 And hold her tight So happy together 00:10:52.419 --> 00:10:58.457 I can't see me loving nobody but you 00:10:58.458 --> 00:11:02.028 For all my life 00:11:02.029 --> 00:11:07.233 When you're with me, da-da-da Blue, da-da 00:11:07.234 --> 00:11:13.039 You for all my life Imagine me and you 00:11:13.040 --> 00:11:19.644 I do Wow. Sweet. 00:11:19.769 --> 00:11:23.769 It's only right to think about the girl you love 00:11:23.770 --> 00:11:28.970 And hold her tight so happy together 00:11:30.389 --> 00:11:35.961 Yeah, yeah. I know. But we were young, and we had lots of time on our hands. 00:11:39.565 --> 00:11:42.401 That is playing with your food, which is bad. 00:11:42.402 --> 00:11:45.937 These are your sister Joanie's tomatoes, so, technically, 00:11:45.938 --> 00:11:51.143 I'm playing with Joanie's food. I'm playing with Joanie's tomatoes. 00:11:51.144 --> 00:11:53.746 - I think he has a point. - I don't like tomatoes. 00:11:53.747 --> 00:11:55.748 - I don't like tomatoes. - I do have a point. 00:11:55.749 --> 00:11:57.583 - I like tomatoes. - No, you don't. 00:11:57.584 --> 00:12:00.453 - You do? I didn't know that. - Then you can have my tomatoes. 00:12:00.454 --> 00:12:02.488 Paul, give Louise my tomatoes. 00:12:02.489 --> 00:12:05.625 No, I don't need any tomatoes. I just... You guys are so cute together. 00:12:05.626 --> 00:12:08.327 And I hear the thumpity thump is... 00:12:08.328 --> 00:12:10.429 - Joan! - Louise! 00:12:10.430 --> 00:12:11.998 The what? The thumpity what? 00:12:11.999 --> 00:12:13.966 - I think they probably... - I can't believe you told her. 00:12:13.967 --> 00:12:16.002 - I didn't know it was a secret. - Nothing. 00:12:16.003 --> 00:12:18.638 I told them you were good at vegetable animals. Really good. 00:12:18.639 --> 00:12:21.607 I like to think that my work speaks for itself. 00:12:21.608 --> 00:12:24.777 - So lifelike. - I can't believe you told her. 00:12:24.778 --> 00:12:28.014 This is gonna go down in history as the greatest vegetable animal 00:12:28.015 --> 00:12:30.016 - ...of all time, ever. - I didn't tell her much. 00:12:30.017 --> 00:12:34.053 Of all time. Do you see this dinosaur that I've created in this restaurant? 00:12:34.054 --> 00:12:35.922 - Excuse me. Look at this. - No. 00:12:35.923 --> 00:12:37.335 It's not a real dinosaur. 00:12:37.336 --> 00:12:42.862 It's a triceratops made of fruit and vegetables. Don't be afraid. It's gentle. 00:12:42.863 --> 00:12:45.097 - See? - We call him Larry. 00:12:45.098 --> 00:12:47.833 You smell like fruit, Larry. 00:12:47.834 --> 00:12:50.869 - You smell like cantaloupe. - I'm sorry you're a prude. 00:12:53.940 --> 00:12:58.577 Let's conclude. We have a proposition, a thesis of sorts, 00:12:58.578 --> 00:13:02.515 that certain breast cancers are inherited. No one else believes this. We do. 00:13:02.516 --> 00:13:05.717 To prove it, we have to do four things. Sarah? First? 00:13:05.718 --> 00:13:08.563 Find a group of women who have breast cancer, 00:13:08.564 --> 00:13:11.409 and from within that group, women who have relatives... 00:13:11.410 --> 00:13:14.293 - who have breast cancer. - Second? 00:13:14.294 --> 00:13:20.375 We then need to find a way to track the inheritance of our breast cancer gene... 00:13:20.376 --> 00:13:24.236 - from generation to generation. - Third? 00:13:24.538 --> 00:13:30.409 Even if we manage to map the gene to a specific chromosome, 00:13:30.410 --> 00:13:34.269 we then need to isolate and sequence it to find the mutation, 00:13:34.270 --> 00:13:38.117 which will take years. And then, uh... 00:13:38.118 --> 00:13:40.885 then we find out if it repeats in the relatives. And if it does, 00:13:40.886 --> 00:13:44.015 - then that is our link. - Fourth? 00:13:44.024 --> 00:13:47.726 Fourth and, realistically, maybe the most difficult. 00:13:47.728 --> 00:13:52.631 We then need to figure out why a mutation in a single gene... 00:13:52.632 --> 00:13:54.700 could lead to breast cancer in so many women. 00:13:54.701 --> 00:13:58.303 Wonderful. See you first thing. 00:14:17.490 --> 00:14:20.359 - Hey. - Why are you playing in the van? 00:14:20.360 --> 00:14:23.686 - The acoustics in here are incredible. - Slow day, then? 00:14:23.687 --> 00:14:29.369 Strange as it may seem, no one wants their pool service this time of year. 00:14:30.771 --> 00:14:34.540 And look at me. I'm a Canadian pool man. 00:14:34.541 --> 00:14:38.778 I'm like one of those... those oxy... oxy... 00:14:38.779 --> 00:14:42.081 - Morons. - Morons. 00:14:42.082 --> 00:14:44.116 Yes. 00:14:44.117 --> 00:14:46.218 I'm gonna go inside. 00:14:46.820 --> 00:14:48.821 Oh. 00:14:48.822 --> 00:14:51.157 Okay. Well... 00:14:52.259 --> 00:14:57.595 I was kind of thinking maybe you should hang out here for a bit. 00:15:00.066 --> 00:15:01.734 Sha-la-la-la-la 00:15:01.735 --> 00:15:03.736 Live for today 00:15:03.737 --> 00:15:06.071 Sha-la-la-la-la 00:15:06.072 --> 00:15:08.707 Live for today... 00:15:08.708 --> 00:15:14.145 Yeah, yeah. I know. But we were young, and we had lots of time on our hands. 00:15:14.447 --> 00:15:17.182 Thumpity thumpity thump. 00:15:22.822 --> 00:15:24.923 Gee. 00:15:35.501 --> 00:15:37.902 Paul? 00:15:42.775 --> 00:15:45.143 Paul? 00:15:45.545 --> 00:15:47.746 What are you doing? 00:15:47.747 --> 00:15:51.215 Nothing. Just, you know, practicing. 00:15:52.151 --> 00:15:56.154 - You okay? - Yeah. 00:16:07.166 --> 00:16:08.467 Paul! 00:16:08.468 --> 00:16:12.004 - Paul! - What? 00:16:12.005 --> 00:16:14.573 - Joanie! - Oh! 00:16:14.574 --> 00:16:15.875 - Joanie! - What's going on? 00:16:15.876 --> 00:16:17.276 - She's pregnant. - Paul. 00:16:17.277 --> 00:16:20.869 - No, I mean, you know... - Oh, my God! Honey! 00:16:20.870 --> 00:16:22.146 You're gonna be a new mommy. 00:16:22.147 --> 00:16:24.483 - Okay. - Shit! 00:16:25.085 --> 00:16:29.088 He's... He's good-looking. 00:16:29.089 --> 00:16:32.591 For a baby, you know. In an ugly kind of way. 00:16:32.592 --> 00:16:37.194 He's got bass player hands. 00:16:38.163 --> 00:16:41.734 I mean, I'm not saying that, you know, babies are ugly. 00:16:41.735 --> 00:16:46.871 They just got that kind of ugly baby thing going. 00:16:59.885 --> 00:17:03.422 You need to borrow 00:17:03.423 --> 00:17:05.291 Like the platforms 00:17:05.292 --> 00:17:09.461 For no one can fill 00:17:09.462 --> 00:17:11.764 All of those needs 00:17:11.765 --> 00:17:15.200 That you won't let show 00:17:15.201 --> 00:17:18.971 - You just call on me, sister - Hey. 00:17:18.972 --> 00:17:22.606 - When you need a hand - Joanie. Hey. 00:17:25.010 --> 00:17:29.515 After you had your baby, did you, like... 00:17:30.417 --> 00:17:33.018 do it less? 00:17:33.019 --> 00:17:35.554 Honey, have you and Paul been... 00:17:35.555 --> 00:17:39.357 It's really bad. We're down to, like... 00:17:40.759 --> 00:17:43.395 four times a week now. 00:17:47.800 --> 00:17:50.301 Are you serious? 00:17:50.403 --> 00:17:54.239 - That's actually quite a lot, Annie. - It is? 00:17:54.240 --> 00:17:56.374 Yeah. 00:17:58.510 --> 00:18:01.813 - Sorry. - Don't you dare! 00:18:04.817 --> 00:18:07.085 No. No. 00:18:13.058 --> 00:18:15.427 - Joanie, what's wrong? - Are you okay? 00:18:15.428 --> 00:18:20.032 - You all right? - I'm sorry. It's just I... Excuse me. 00:18:20.934 --> 00:18:23.101 Joan? 00:18:25.637 --> 00:18:27.072 I'm sorry. Did I hurt you? 00:18:27.073 --> 00:18:30.175 Oh, come on, Annie. I make you cry, remember? 00:18:30.176 --> 00:18:32.678 What is it? 00:18:34.080 --> 00:18:35.814 Um... 00:18:36.716 --> 00:18:39.218 Well, it might not be as bad as it sounds. 00:18:39.219 --> 00:18:41.253 Joan? 00:18:41.254 --> 00:18:45.791 I found a lump... in my breast. 00:18:47.193 --> 00:18:49.862 But you're gonna be all right. Okay? Yeah? 00:18:49.863 --> 00:18:51.263 You're gonna be just fine. 00:18:51.264 --> 00:18:52.798 - Snap. - Snap. 00:18:52.799 --> 00:18:55.833 - I'm gonna be fine. - Yeah. Yeah. 00:18:57.536 --> 00:19:01.673 - I love you. - I love you, honey. 00:19:01.674 --> 00:19:04.476 - My big sister. - That's right. 00:19:05.378 --> 00:19:08.046 Four times a week. 00:19:08.548 --> 00:19:09.882 Really? 00:19:09.883 --> 00:19:13.052 Do you remember the man in the room upstairs? 00:19:13.053 --> 00:19:16.688 - It wasn't a man, it was death. - Shh! 00:19:16.689 --> 00:19:20.926 What, you think if we don't say it, it'll go away? 00:19:20.927 --> 00:19:23.395 Okay, I'll whisper. 00:19:24.497 --> 00:19:27.098 Did you ever go in there? 00:19:31.704 --> 00:19:34.106 Just once. 00:19:34.808 --> 00:19:37.308 Right before... 00:19:40.512 --> 00:19:43.382 No. I never did. 00:19:43.383 --> 00:19:47.352 Joanie! It's not funny. It's so not funny. 00:19:47.353 --> 00:19:49.989 - I can't stop thinking about it. - Death? 00:19:49.990 --> 00:19:53.224 Shh! Yeah. 00:19:53.326 --> 00:19:56.428 - And... - Cancer? 00:19:56.429 --> 00:19:58.596 Yeah. 00:19:58.798 --> 00:20:01.266 It's stalking us. 00:20:01.568 --> 00:20:04.969 Oh, you mean like that guy you met at the Leafs game who kept... 00:20:04.970 --> 00:20:08.574 calling you and sending you chocolate hearts, 00:20:08.575 --> 00:20:11.376 and then he parked outside our house, and... 00:20:11.377 --> 00:20:15.580 Dad caught him jerking off into Hockey News? 00:20:19.218 --> 00:20:21.519 Yeah. 00:20:21.621 --> 00:20:23.689 Like him. 00:20:23.690 --> 00:20:25.991 Because I'm scared. 00:20:25.992 --> 00:20:29.928 I'm really, really scared that it's inside of us, 00:20:29.929 --> 00:20:32.397 it's in our family. 00:20:33.099 --> 00:20:38.169 Sweetie... that's not true. 00:20:43.775 --> 00:20:47.712 I'm sorry. I'm sorry. 00:20:48.014 --> 00:20:52.583 Don't be. I like it when you're worried. 00:20:54.353 --> 00:20:58.589 I like it when you have lots of problems. 00:21:21.313 --> 00:21:24.282 It's gonna be really hard without Joanie. 00:21:26.051 --> 00:21:28.186 I know. 00:21:28.588 --> 00:21:31.023 - I know. - Come here. 00:21:31.024 --> 00:21:34.193 Come here. Come here. 00:21:34.194 --> 00:21:39.264 Well, at least she went quick. Not like my wife. 00:21:39.265 --> 00:21:44.102 Boy, she took her time, didn't she? I mean, it was endless suffering. 00:21:44.103 --> 00:21:46.237 Endless. 00:21:49.575 --> 00:21:51.977 My God. 00:21:51.978 --> 00:21:57.649 First your mother, then your father. 00:21:57.650 --> 00:22:01.685 Now... poor Joan. 00:22:13.665 --> 00:22:17.502 You again? Cool. 00:22:17.503 --> 00:22:21.039 You know, a lot of women can't be hot 00:22:21.040 --> 00:22:23.175 and in mourning at the same time, 00:22:23.176 --> 00:22:26.844 but you... you pull it off. 00:22:29.381 --> 00:22:34.752 I don't mean any disrespect, but when you think about it, 00:22:35.054 --> 00:22:38.710 isn't sex our way of saying 00:22:38.711 --> 00:22:42.350 "fuck you" to death? 00:22:44.330 --> 00:22:47.965 How are you still working here? 00:22:55.574 --> 00:22:59.278 The thing was, I started thinking about it all the time... 00:22:59.279 --> 00:23:01.612 my family and death. 00:23:01.714 --> 00:23:04.116 Watching me, waiting, 00:23:04.117 --> 00:23:08.954 hiding in a closet or parked outside the house, the Hockey News. 00:23:10.256 --> 00:23:13.423 Oh, you might feel some discomfort. 00:23:15.194 --> 00:23:17.262 Beautiful day today. 00:23:17.263 --> 00:23:20.932 Though I'm stuck in here, it looked lovely through the window. 00:23:20.933 --> 00:23:26.637 And I spoke to your husband. He explained you were very worried. 00:23:27.573 --> 00:23:30.242 He said I was feeling myself up, right? 00:23:30.243 --> 00:23:35.012 Checking, yes. Perfectly understandable once in a while. 00:23:36.148 --> 00:23:38.615 He said once in a while? 00:24:19.491 --> 00:24:21.460 Yeah. 00:24:21.461 --> 00:24:25.696 Oh, yeah. Keep talking. Oh, keep talking. 00:24:30.001 --> 00:24:34.139 You know, there is a simple check you can do for testicular cancer. 00:24:34.140 --> 00:24:36.274 I heard about this. 00:24:36.275 --> 00:24:40.412 Baby, do you want me to check you now while I'm down there? 00:24:40.413 --> 00:24:42.381 - Come on. - Annie. Annie. 00:24:42.382 --> 00:24:45.150 What? Oh, what? 00:24:45.151 --> 00:24:50.655 He mentioned that perhaps you were overly concerned. 00:24:51.557 --> 00:24:55.727 I know your family history. It's very sad. 00:24:55.728 --> 00:24:59.965 But that doesn't mean that you're going to get cancer. 00:24:59.966 --> 00:25:05.204 Look, Anne. White coat, stethoscope. You can trust me. 00:25:05.205 --> 00:25:07.339 No more worrying, okay? 00:25:07.340 --> 00:25:11.075 - Okay. - Good. That's my girl. 00:25:17.549 --> 00:25:20.852 I don't know about genetics. I know about computers. 00:25:20.853 --> 00:25:24.489 You see, I make these cards, and then I load them into the front of the computer, 00:25:24.490 --> 00:25:27.626 along with everyone else's, and then, usually the next day sometime, 00:25:27.627 --> 00:25:30.128 depending on how many other people are using the computer, 00:25:30.129 --> 00:25:35.333 maybe a few days later, I get this printout. And there you go. 00:25:35.334 --> 00:25:37.936 And for the amount of data we're going to have, how fast? 00:25:37.937 --> 00:25:42.234 The university's mainframe computer weighs 21/2 tons. It's capable of storing... 00:25:42.235 --> 00:25:45.911 - 700 kilobytes of data. - I'm sorry. How long? 00:25:46.813 --> 00:25:51.350 Once we get the data, make a program and then load it... 00:25:52.552 --> 00:25:54.919 Ten years? 00:26:00.392 --> 00:26:02.093 Will? 00:26:02.094 --> 00:26:04.463 - Yeah? - Honey. 00:26:04.464 --> 00:26:07.032 Come on. Get up. 00:26:07.033 --> 00:26:09.901 - I'm up. - No, no, no. 00:26:09.902 --> 00:26:12.938 If you're not out of bed, you're not up. 00:26:12.939 --> 00:26:14.973 Hey. 00:26:15.875 --> 00:26:19.511 - You're not gonna have breakfast? - Uh... No, I can't. 00:26:19.512 --> 00:26:22.613 Work. Got a new client. 00:26:23.815 --> 00:26:26.351 They called this morning. 00:26:26.352 --> 00:26:30.253 - Kiss? - I'm already late, Annie. 00:26:32.491 --> 00:26:37.962 What? Hey, I'm a musician, okay? It's a look. 00:26:39.564 --> 00:26:41.632 Okay. 00:26:46.371 --> 00:26:50.375 When I grow up, I'm gonna be a pool man, like Dad. 00:26:50.376 --> 00:26:54.846 Do you, sweetie? Oh, that's so nice. 00:26:54.847 --> 00:26:58.916 Well, maybe when you're a little older, we'll talk about it, okay? 00:27:01.019 --> 00:27:03.621 Mommy's gonna go take a shower. 00:27:43.094 --> 00:27:46.830 Mommy loves you, okay? Have a great day. 00:28:02.014 --> 00:28:04.615 All right. 00:28:04.917 --> 00:28:07.084 Anne... 00:28:09.020 --> 00:28:14.524 your biopsy shows that you have carcinoma of the left breast. 00:28:15.360 --> 00:28:18.663 Phew. And I thought it was gonna be really bad news. 00:28:18.664 --> 00:28:22.300 Well, it's quite advanced, I'm afraid. 00:28:22.301 --> 00:28:26.204 But what I recommend would be surgery. 00:28:26.205 --> 00:28:27.906 - Surgery? - Mm-hmm. 00:28:27.907 --> 00:28:32.377 What's known as a modified radical mastectomy. 00:28:33.079 --> 00:28:36.448 - Oh, God. - I'm sorry, Anne. 00:28:36.449 --> 00:28:42.085 The surgery would require, I'm afraid, the removal of the entire breast, 00:28:42.086 --> 00:28:46.390 as well as most of your underarm lymph nodes. 00:28:46.692 --> 00:28:51.628 Oh, God. Oh, God. William. 00:28:53.331 --> 00:28:56.835 I'm scared. I'm really scared. 00:28:57.937 --> 00:28:59.604 I don't want to suffer. 00:28:59.605 --> 00:29:01.640 - I know. I know. - I don't want to suffer. 00:29:01.641 --> 00:29:04.509 I don't want to die. 00:29:05.211 --> 00:29:07.746 Oh, God. 00:29:08.648 --> 00:29:10.682 Oh, God. 00:29:11.584 --> 00:29:13.684 Oh, God. 00:29:33.805 --> 00:29:35.507 Hey. 00:29:35.508 --> 00:29:37.775 Hey. 00:29:43.081 --> 00:29:45.716 How you doing? 00:29:47.118 --> 00:29:50.621 Hey, you want an ice chip? 00:29:59.531 --> 00:30:01.565 Oh. 00:30:06.705 --> 00:30:09.406 Can I have one? 00:30:10.675 --> 00:30:15.347 This is really good ice. Oh, my God. 00:30:17.249 --> 00:30:21.219 Oh, my God. Wow. It's really good. 00:30:21.821 --> 00:30:25.123 Ow. It hurts. Don't make me laugh. 00:30:25.124 --> 00:30:28.525 What? Oh, don't... Oh. 00:30:36.301 --> 00:30:39.002 It really hurts. 00:31:20.044 --> 00:31:23.448 - And how are we feeling today? - Not too good. 00:31:23.449 --> 00:31:26.983 - Oh? - I had a breast removed. 00:31:27.786 --> 00:31:32.257 - Of course. What I meant... - I'm feeling all right, considering. 00:31:32.258 --> 00:31:34.692 Good. 00:31:35.094 --> 00:31:38.730 But, you know, I just knew this was gonna happen. 00:31:38.731 --> 00:31:43.101 It happened to my mom, happened to my sister, and it happened to my grandma... 00:31:43.102 --> 00:31:48.340 Many women feel that way and, yes, your family did have a bit of bad luck, 00:31:48.341 --> 00:31:50.786 - but there are many complex factors... - It's not bad luck. 00:31:50.787 --> 00:31:55.413 There's some evidence that certain people have a predisposition 00:31:55.414 --> 00:31:59.918 - based on diet or environmental factors... - Excuse me a minute. 00:32:01.920 --> 00:32:03.922 What are you doing? 00:32:03.923 --> 00:32:06.457 Well, there's just some interesting current research that suggests... 00:32:06.458 --> 00:32:11.062 Look, rejection of orthodoxy always seems within the purview of the young doctor. 00:32:11.063 --> 00:32:12.530 I don't know what my age has to do with that. 00:32:12.531 --> 00:32:15.800 However, to mislead is irresponsible. 00:32:15.801 --> 00:32:18.636 There have always been articles. There always will be articles. 00:32:18.637 --> 00:32:22.607 But because some theory is new doesn't make it right. Proof makes it right. 00:32:22.608 --> 00:32:26.845 And I've seen no recent evidence concerning alternative treatment for cancer 00:32:26.846 --> 00:32:29.314 which would lead me to alter the views I've acquired 00:32:29.315 --> 00:32:32.616 over 40 years of practicing medicine. 00:32:33.618 --> 00:32:36.553 - I understand. - Good. 00:32:39.057 --> 00:32:41.191 Good. 00:32:45.363 --> 00:32:49.534 Hey, if you wanna talk some more, you can just give me a call. 00:32:49.535 --> 00:32:52.737 - Oh, thanks a lot, Dr... - Doctor! 00:32:53.439 --> 00:32:55.773 Sean is fine. 00:32:55.774 --> 00:32:58.109 - Anne, right? - Annie. 00:32:58.110 --> 00:33:00.044 Annie. 00:33:00.045 --> 00:33:02.146 Thanks. 00:33:02.748 --> 00:33:07.118 Let me tell you, I'm gonna be the best nurse you have ever had. 00:33:07.119 --> 00:33:11.922 And I think I already am, because you can't make out with your other nurses. 00:34:11.249 --> 00:34:15.718 Mommy was in the hospital because Mommy has cancer. 00:34:16.754 --> 00:34:20.892 - Didn't Aunt Joan have cancer? - Yeah, she did, sweetie. 00:34:20.893 --> 00:34:23.528 But she died. 00:34:23.529 --> 00:34:25.596 Yeah, she did. 00:34:25.597 --> 00:34:29.067 - Are you gonna die? - Hey, no. 00:34:29.068 --> 00:34:31.302 I promise you. 00:34:31.303 --> 00:34:35.006 You are not gonna lose your mommy to cancer. 00:34:35.007 --> 00:34:37.408 But how do you know? 00:34:37.409 --> 00:34:42.012 Because I just know. I'm not gonna die. 00:35:14.379 --> 00:35:16.381 Wait. 00:35:16.382 --> 00:35:19.249 I wanna come with you. 00:35:20.451 --> 00:35:24.187 - I'm not going anywhere. - You're going to work. 00:35:24.756 --> 00:35:26.457 That's not anywhere. 00:35:26.458 --> 00:35:29.227 Aren't you cleaning Louise and Steve's pool today? 00:35:29.228 --> 00:35:33.597 I wanna come with you. Come on. It'll be fun. 00:35:34.299 --> 00:35:36.533 Please? 00:35:39.237 --> 00:35:41.705 Come on, then. 00:35:45.777 --> 00:35:48.747 - Let's get in. - Yeah, right. 00:35:48.748 --> 00:35:50.215 I'm serious. 00:35:50.216 --> 00:35:53.885 - Uh, we're not getting in. - Why not? 00:35:53.886 --> 00:35:56.320 Because I don't want to, 00:35:56.321 --> 00:36:01.359 and because I'm a pool man, and pool men don't get into people's pools. 00:36:01.360 --> 00:36:05.528 Is that, like, the pool man's code of ethics or something? 00:36:09.467 --> 00:36:11.535 Why is the water green? 00:36:11.536 --> 00:36:16.107 Because Louise's dumbfuck husband only has me come once a month. 00:36:16.108 --> 00:36:19.510 No. No, I mean, really, why is it green? 00:36:19.511 --> 00:36:24.215 Oh, that's... that's algae. It's there because the pH balance of the pool is off. 00:36:24.216 --> 00:36:28.719 It can't be too acid or too base. It needs to be around 7.5, 00:36:28.720 --> 00:36:32.224 the same pH as human tears. 00:36:32.225 --> 00:36:34.358 Aw. 00:36:34.460 --> 00:36:36.527 See, if you, uh... 00:36:36.528 --> 00:36:40.298 If you don't put chlorine in, you get phosphates, 00:36:40.299 --> 00:36:43.000 and algae feeds on phosphate. 00:36:43.001 --> 00:36:47.405 But if you put chlorine in, the algae will die. 00:36:47.406 --> 00:36:52.742 But you can't be a dumbfuck and only have your pool man come once a month. 00:36:54.379 --> 00:36:57.248 Are you gonna keep wearing eye makeup? 00:36:57.249 --> 00:37:00.316 Yeah, I am. 00:37:03.321 --> 00:37:05.527 I'm gonna get something to drink. You want something? 00:37:05.528 --> 00:37:09.217 Nah. I'll stay here. 00:37:12.163 --> 00:37:15.433 I didn't know if the pool was green because Paul was a bad pool man 00:37:15.434 --> 00:37:19.936 or because Louise's husband was a dumbfuck. But it made me think. 00:37:25.576 --> 00:37:28.947 "Breast cancer. See cancer." 00:37:28.948 --> 00:37:30.748 Okay. 00:37:30.749 --> 00:37:33.751 "Cancer. Any malignant growth or tumor 00:37:33.752 --> 00:37:39.022 caused by abnormal uncontrolled cell divisions." 00:37:42.894 --> 00:37:45.595 William? 00:37:45.697 --> 00:37:49.900 - Willy, Mommy needs the bathroom. - Number one or number two? 00:37:50.102 --> 00:37:52.303 Number one or number two? 00:38:14.458 --> 00:38:18.997 Mommy's gonna buy you a new backpack. Okay? 00:38:23.467 --> 00:38:25.937 Hi. Sorry. I'm, uh... 00:38:25.938 --> 00:38:29.207 - Where are you off to? - Detroit. 00:38:29.208 --> 00:38:33.478 - Gotta run. Hope you're well. - I am fine. What about our coffee? 00:38:34.780 --> 00:38:37.147 You're late. 00:38:39.050 --> 00:38:41.485 - What's going on? - Allen, you got here too late. 00:38:41.486 --> 00:38:43.988 - You're late. - I know, I know. I'm late, I'm late. 00:38:43.989 --> 00:38:47.592 We have news. We've identified a dozen high-risk families... 00:38:47.593 --> 00:38:49.494 50-some cancer cases between them. 00:38:49.495 --> 00:38:51.596 - Good. And so? - So? 00:38:51.597 --> 00:38:54.332 So now we can begin to look for correlations in earnest. 00:38:54.333 --> 00:38:56.434 We need to interview them, get blood samples, 00:38:56.435 --> 00:38:58.736 extract the DNA, and then begin to look for markers. 00:38:58.737 --> 00:39:01.339 - Okay. "Markers"? - Genetic markers. 00:39:01.340 --> 00:39:05.509 We can track them through the families, like a signpost on a highway. 00:39:05.510 --> 00:39:07.611 Say you have two stretches of road in the desert... 00:39:07.612 --> 00:39:09.863 - And they look exactly the same. - But if you pass signposts, 00:39:09.864 --> 00:39:11.065 you can measure the intervals... 00:39:11.066 --> 00:39:12.950 And you can identify the different stretches of road. 00:39:12.951 --> 00:39:14.986 - Even if they look... - And if those markers 00:39:14.987 --> 00:39:19.256 are next to something like the breast cancer gene, it can be identified. 00:39:37.975 --> 00:39:43.046 What is it with the magazine selection in doctors' offices? 00:39:43.248 --> 00:39:45.615 Hello. 00:39:45.717 --> 00:39:48.519 Field & Stream? 00:39:49.221 --> 00:39:53.957 Do a lot of your patients show up wearing camouflage bibs, 00:39:54.359 --> 00:39:58.296 a bag full of decoys, and making duck calls? 00:39:58.297 --> 00:40:01.064 I don't know, ma'am. 00:40:01.166 --> 00:40:04.836 I would think that you would notice something like that. 00:40:04.837 --> 00:40:08.171 Like I said, I don't know. 00:40:11.375 --> 00:40:13.977 Quack. 00:40:16.514 --> 00:40:18.749 Quack. 00:40:19.651 --> 00:40:22.153 Quack. 00:40:22.154 --> 00:40:23.788 Quack quack. 00:40:23.789 --> 00:40:25.556 Quack. 00:40:25.557 --> 00:40:27.724 Quack. 00:40:29.760 --> 00:40:31.695 Nice office. 00:40:32.597 --> 00:40:37.234 It's not mine. Dr. Benton takes long lunches. I figure it's not hurting anybody. 00:40:37.235 --> 00:40:42.173 It was either here or the cafeteria, and the floors are much stickier there. 00:40:42.174 --> 00:40:44.175 Are you sure you won't get into any trouble? 00:40:44.176 --> 00:40:46.776 I'm a doctor. I can't get in trouble. 00:40:50.214 --> 00:40:52.950 What can I tell you? I'm mostly lab-based, 00:40:52.951 --> 00:40:56.921 but I can tell you what I know. 00:40:57.823 --> 00:41:00.256 Why do I have cancer? 00:41:02.093 --> 00:41:04.161 That's a big question. 00:41:04.162 --> 00:41:07.965 There's no one answer. So many factors involved. 00:41:07.966 --> 00:41:11.267 I had a feeling that you might say that. 00:41:12.536 --> 00:41:15.005 You know, I had a teacher once who told me 00:41:15.006 --> 00:41:17.341 what the ideal breast cancer patient would be. 00:41:17.342 --> 00:41:21.746 He said the person with the highest risk would be a nun living in a cold climate, 00:41:21.747 --> 00:41:25.116 who was overweight, who ate red meat, who was breast fed, 00:41:25.117 --> 00:41:27.552 whose mother and sister had premenopausal breast cancer, 00:41:27.553 --> 00:41:30.520 and who was Ashkenazi Jewish. 00:41:36.127 --> 00:41:37.628 Not a great start, 00:41:37.629 --> 00:41:41.798 but he gave me a pile of books, and I promised to read them. 00:41:56.213 --> 00:41:58.849 Doesn't make any sense. 00:42:08.826 --> 00:42:11.562 Oh, shit! 00:42:12.464 --> 00:42:14.165 Good, good! Ohh! 00:42:14.166 --> 00:42:15.833 The puck has cleared it behind... 00:42:15.834 --> 00:42:18.836 You know, it's been hard for him, too, with everything. 00:42:18.837 --> 00:42:25.176 It's not like he gets... any attention. 00:42:25.177 --> 00:42:27.244 You're right, you know? I'm being selfish. 00:42:27.245 --> 00:42:30.180 No. That's not what I meant. 00:42:31.082 --> 00:42:35.486 You're right. Maybe I am. 00:42:36.388 --> 00:42:40.725 You know, I feel sorry for Paul. I do, and I... 00:42:42.127 --> 00:42:45.094 I feel sorry for me, too, but... 00:42:47.798 --> 00:42:50.300 You know what I feel most of all? 00:42:52.270 --> 00:42:54.337 What? 00:42:56.574 --> 00:42:59.409 I just wanna be touched. 00:43:02.079 --> 00:43:05.615 - Come here. - Come on. 00:43:08.285 --> 00:43:11.220 Come here. Come here. 00:43:21.632 --> 00:43:24.268 Okay. 00:43:24.269 --> 00:43:26.803 So this is something we need to look at. 00:43:29.974 --> 00:43:32.308 Don't mind me. 00:43:34.144 --> 00:43:37.948 So does that mean I have to eat nothing but grapefruit or something? 00:43:37.949 --> 00:43:39.617 No, no. It's nothing that severe. 00:43:39.618 --> 00:43:43.187 Although studies have shown that foods high in fat, fried foods... 00:43:43.188 --> 00:43:47.091 - Japanese women. - Pardon me? 00:43:47.092 --> 00:43:50.294 They eat very little red meat, and they have a much lower rate 00:43:50.295 --> 00:43:52.162 of breast cancer than North American women. 00:43:52.163 --> 00:43:54.765 Is that so? 00:43:55.467 --> 00:43:57.335 Yeah. 00:43:59.437 --> 00:44:01.572 - So did your family go out... - Three different tests. 00:44:01.573 --> 00:44:05.542 One was over ten years. It's fairly conclusive. 00:44:08.913 --> 00:44:11.714 Anyway, I'm gonna get going. 00:44:17.354 --> 00:44:20.090 - So... - We can't know anything. 00:44:20.091 --> 00:44:22.126 There's so many possible factors. 00:44:22.127 --> 00:44:25.529 It could be diet. It could be toxins in the home. 00:44:25.530 --> 00:44:28.965 One of a thousand viruses known or unknown. 00:44:29.267 --> 00:44:31.602 They know the groups that have the highest incidents. 00:44:31.603 --> 00:44:34.772 They don't know the elements common to those groups. 00:44:34.773 --> 00:44:38.510 We don't know what happened to your family. We may never know. 00:44:40.412 --> 00:44:45.382 My mom used to wrap hot dogs in bacon, and they deep-fried them. 00:44:49.453 --> 00:44:52.723 - What's this? - It's dinner. 00:44:52.724 --> 00:44:55.325 Where's the rest of it? 00:44:55.527 --> 00:44:58.928 That's it. It's a salad. 00:45:01.398 --> 00:45:04.768 It's got tomatoes in it. I hate tomatoes. 00:45:05.270 --> 00:45:07.871 You can pick them out. 00:45:11.241 --> 00:45:14.410 Is everything okay? 00:45:15.512 --> 00:45:18.180 Yeah. Yeah. 00:45:23.120 --> 00:45:28.290 You know what? Um, I'm gonna go get us some burgers. 00:45:29.259 --> 00:45:30.604 You want one? 00:45:30.605 --> 00:45:33.797 Yeah! But no tomatoes and no oniony things. 00:45:33.798 --> 00:45:37.726 No tomatoes and no oniony things. Okay. 00:45:37.927 --> 00:45:40.360 You want one? 00:45:48.912 --> 00:45:50.781 Why are we looking at Mormons and Jews? 00:45:50.782 --> 00:45:53.017 Mormons tend to have very large families, 00:45:53.018 --> 00:45:55.653 which makes them excellent genetic resources. 00:45:55.654 --> 00:45:57.421 Plus the Church of Latter Day Saints 00:45:57.422 --> 00:46:02.126 believes everyone related to the Mormons has to be baptized to be saved later. 00:46:02.127 --> 00:46:05.262 So, what, there's carcinogens in the baptismal water they're using? 00:46:05.263 --> 00:46:09.867 No. But they keep incredibly detailed records of their familial ties. 00:46:09.868 --> 00:46:15.372 A researcher before us found 30 cases of breast cancer in one family. 00:46:15.373 --> 00:46:16.940 Called the Kindred 107. 00:46:16.941 --> 00:46:18.976 Ashkenazi Jews are important, Tom, because 00:46:18.977 --> 00:46:21.645 they have an extraordinarily high rate of breast cancer. 00:46:21.646 --> 00:46:25.416 - In New York, it's an epidemic. - Okay. But... 00:46:25.417 --> 00:46:27.317 why couldn't it be the water or the air? 00:46:27.318 --> 00:46:29.887 If that was true, it would be true of all women in the area. 00:46:29.888 --> 00:46:32.189 Breathing the same air, drinking the same water. 00:46:32.190 --> 00:46:34.691 - But it's not. - So it's something in them. 00:46:34.692 --> 00:46:37.093 In their genes. 00:46:37.118 --> 00:46:40.118 SharePirate.Com-Movie Stream and Downloads 00:46:51.842 --> 00:46:54.611 You're early. Dr. Gold's not here. 00:46:55.313 --> 00:46:57.848 So how did you know all that stuff the other day? 00:46:57.849 --> 00:47:01.584 - What stuff? - The medical stuff. 00:47:03.954 --> 00:47:07.565 - I used to be a nurse. - You used to be a nurse? 00:47:07.566 --> 00:47:09.649 - Yep. - What happened? 00:47:09.650 --> 00:47:14.365 What do you mean, "what happened"? You don't think I enjoy this? Yes? 00:47:14.366 --> 00:47:15.966 Okay. 00:47:15.967 --> 00:47:19.770 Mr. Elson, you can take your wife through to the back with the nurse. 00:47:20.972 --> 00:47:24.141 Seriously, what happened? 00:47:25.043 --> 00:47:26.877 Uh... 00:47:27.779 --> 00:47:31.381 I used to work in the oncology ward. 00:47:31.382 --> 00:47:35.586 But it was too much, so I quit. 00:47:36.488 --> 00:47:40.322 You're right. Cancer patients are a pain in the ass. 00:47:42.259 --> 00:47:44.228 - Sorry. - Hello. 00:47:44.229 --> 00:47:47.498 Yes, Doctor, the tests will be ready this afternoon. 00:47:47.499 --> 00:47:51.301 No, Doctor. I would've told you. Okay. Bye-bye. 00:47:52.003 --> 00:47:55.105 - You're right. - About what? 00:47:55.106 --> 00:47:57.641 You're all a pain in the ass. 00:47:58.143 --> 00:48:00.310 That's true. 00:48:01.212 --> 00:48:03.914 - He likes you, you know. - Who? 00:48:03.915 --> 00:48:06.049 Dr. Gold? 00:48:06.050 --> 00:48:07.918 Yeah, him. 00:48:07.919 --> 00:48:10.921 - No. - Yes, he does. 00:48:10.922 --> 00:48:15.492 - I'm married. - Of course. What was I thinking? 00:48:15.994 --> 00:48:19.763 - Annie. - Hey. Hi. 00:48:20.465 --> 00:48:23.232 Oh. Oh. 00:48:49.459 --> 00:48:52.963 I could've gotten cancer from my mom? Like passed down? 00:48:52.964 --> 00:48:56.900 Uh, there's no evidence that you can get it passed down. 00:48:56.901 --> 00:49:00.671 All cancer is genetic in the end, just not necessarily in the beginning. 00:49:00.672 --> 00:49:02.472 I don't understand. 00:49:02.473 --> 00:49:06.310 When you get cancer, your DNA gets messed up, 00:49:06.311 --> 00:49:11.515 and certain genes can cause your cells to replicate wildly. 00:49:11.516 --> 00:49:15.553 But something has to mess the DNA up in the first place, right? 00:49:15.554 --> 00:49:20.189 - Right. - Well, then, what messes it up? 00:49:20.291 --> 00:49:23.126 We don't know, really. 00:49:25.562 --> 00:49:29.232 I really didn't mean to upset you again. 00:49:29.334 --> 00:49:32.469 It's not you. It's me. 00:49:32.470 --> 00:49:35.438 It's the chemo, I think. You know... 00:49:35.439 --> 00:49:39.710 I even cried at the Leafs game with Paul last night. 00:49:39.711 --> 00:49:41.512 - You did? - Yeah. 00:49:41.513 --> 00:49:46.482 It was a tie, but the players all looked so sad. 00:49:55.325 --> 00:49:57.560 Hey, An... 00:50:03.567 --> 00:50:05.535 Hey, hon. 00:50:07.805 --> 00:50:09.605 Hon. 00:50:11.942 --> 00:50:14.144 Annie... 00:50:14.746 --> 00:50:16.813 Why? 00:50:16.814 --> 00:50:20.450 Why? We've got doctors. 00:50:20.451 --> 00:50:25.322 The chemo... is going well... 00:50:26.024 --> 00:50:28.390 you know? 00:50:30.394 --> 00:50:36.600 I've gotta do something. I... Annie... 00:50:37.502 --> 00:50:41.370 Hey, why can't you just leave it alone? 00:50:45.242 --> 00:50:47.678 I really didn't know. 00:50:47.679 --> 00:50:51.281 I think that part more than anything drove him crazy. 00:50:51.282 --> 00:50:56.018 Guys want reasons. I should've made one up. 00:51:34.658 --> 00:51:38.328 I don't know, Annie. Maybe you need to give him time. 00:51:38.329 --> 00:51:40.797 I've given him time. 00:51:41.699 --> 00:51:44.201 Maybe it has something to do with the... 00:51:44.202 --> 00:51:46.636 - You know. The... - What? 00:51:46.637 --> 00:51:50.641 I don't know. All the research. It's a tiny, tiny bit obsessive. 00:51:51.743 --> 00:51:54.912 Obsessive? How? 00:51:54.913 --> 00:51:57.447 You know, like... 00:51:57.749 --> 00:52:00.115 wacko obsessive. 00:52:03.053 --> 00:52:07.790 Wacko obsessive. It's not the bad kind, then. 00:52:10.260 --> 00:52:14.649 It's not too late to reach out to him and to let him know... 00:52:14.650 --> 00:52:16.990 how you feel. 00:52:19.069 --> 00:52:21.370 What, like a blow job? 00:52:24.141 --> 00:52:26.576 Yeah, that's exactly what I mean. 00:52:27.078 --> 00:52:29.579 Have you guys heard of Mary-Claire King? 00:52:29.580 --> 00:52:33.083 She used dental genetics to identify children 00:52:33.084 --> 00:52:36.186 of parents murdered by the junta in Argentina. 00:52:36.187 --> 00:52:42.191 But she is also doing some very interesting work on the genetics of breast cancer. 00:52:43.727 --> 00:52:47.931 So I wrote to Dr. King, and I wrote to her again, 00:52:47.932 --> 00:52:50.534 and I wrote a third and a fourth time. 00:52:50.535 --> 00:52:55.137 I told her my story, my family's story. 00:53:08.285 --> 00:53:13.457 Books were hard for me, so I started making models so I could understand. 00:53:13.458 --> 00:53:18.627 Cells, genes, chromosomes, and a helix. 00:53:22.232 --> 00:53:24.767 I'm going to the bar! 00:53:26.536 --> 00:53:28.505 What? 00:53:28.506 --> 00:53:33.409 I'm going to the effing bar because this is an effing building site! 00:53:34.344 --> 00:53:36.846 I can't hear you! 00:53:37.748 --> 00:53:40.783 I don't fucking believe this. 00:53:40.785 --> 00:53:43.452 I'm going out! 00:53:43.754 --> 00:53:47.056 Hey, watch the rest of the game. Remember the score. 00:53:47.658 --> 00:53:51.660 Paul, would you put William to bed? 00:54:19.022 --> 00:54:22.025 We didn't discover much in that first year, 00:54:22.026 --> 00:54:26.061 but, oddly, that mattered less and less. 00:54:27.731 --> 00:54:30.934 Something mysterious was taking hold of me. 00:54:30.935 --> 00:54:35.337 I didn't know what it was then. That would come later. 00:54:40.143 --> 00:54:41.912 And then, some news. 00:54:41.913 --> 00:54:46.149 Keep having you in to do screenings every six months or so 00:54:46.150 --> 00:54:47.884 just as a precautionary measure, 00:54:47.885 --> 00:54:52.255 but I would say that cancer is out of your life. 00:54:52.256 --> 00:54:55.558 You have reason to celebrate. 00:54:55.860 --> 00:54:57.960 Done? 00:54:58.662 --> 00:55:00.630 I'm done with chemo? 00:55:00.631 --> 00:55:03.433 You're done with chemo. 00:55:45.142 --> 00:55:46.810 Hey. 00:55:46.811 --> 00:55:50.180 Hey. What is this? 00:55:50.181 --> 00:55:54.350 Uh, Louise is watching William. 00:55:54.351 --> 00:56:00.290 Okay. Um, I... I wish you had told me. 00:56:00.291 --> 00:56:03.994 - Why? - 'Cause I have plans. 00:56:03.995 --> 00:56:06.062 - You have plans? - Yeah. 00:56:06.063 --> 00:56:11.066 - What plans? - Just... You know, just plans. 00:56:14.271 --> 00:56:16.138 I... 00:56:19.643 --> 00:56:24.681 Can you just... stay and eat a little bit before you go at least? 00:56:24.682 --> 00:56:27.182 Yeah. Yeah. 00:56:29.019 --> 00:56:30.687 Great. 00:56:30.688 --> 00:56:32.722 Okay. 00:56:37.294 --> 00:56:39.596 Can you change them? 00:56:39.597 --> 00:56:43.165 - What? - Your plans. 00:56:43.567 --> 00:56:46.002 I kind of, uh... 00:56:46.003 --> 00:56:48.672 I made this dinner special for us, you know? 00:56:48.673 --> 00:56:52.384 Thank you. I know you went to... a lot of trouble, 00:56:52.385 --> 00:56:54.644 - and it looks great. I just... - No, no. 00:56:54.645 --> 00:56:58.680 There's no trouble, Paul, you know? 00:57:00.250 --> 00:57:05.521 We're married. Married people do nice things for each other. 00:57:05.823 --> 00:57:07.656 I know. 00:57:07.758 --> 00:57:10.693 They do things together... 00:57:10.995 --> 00:57:14.095 like make love. 00:57:15.865 --> 00:57:20.670 Annie, please, just... We can have sex. 00:57:20.671 --> 00:57:22.672 Don't do this. 00:57:22.673 --> 00:57:25.574 Don't you love me anymore? 00:57:25.976 --> 00:57:29.446 Annie, I do. Hey, I want to. 00:57:29.447 --> 00:57:32.148 - You want to? - No, I... I do. 00:57:32.149 --> 00:57:35.785 Well, then, I don't understand what the problem is. 00:57:36.287 --> 00:57:39.155 Why can't you make love to me anymore? 00:57:39.156 --> 00:57:40.857 Look, I just... I just... I just can't. 00:57:40.858 --> 00:57:43.725 - You can't? - Okay? I can't. 00:57:48.798 --> 00:57:51.701 Oh, is it because I only have one breast? 00:57:51.702 --> 00:57:53.870 - Is that what it is? - Oh, my God, Annie. 00:57:53.871 --> 00:57:58.308 Why don't you just, like, only put it up halfway? Maybe you could get half-erect. 00:57:58.309 --> 00:58:00.977 - Maybe you could close one eye. - Annie, stop it! 00:58:00.978 --> 00:58:05.415 - No, I will not stop it! - Stop it! Stop! I can't touch you! 00:58:05.416 --> 00:58:08.884 Okay? I can't touch you! 00:58:09.186 --> 00:58:11.421 Annie... 00:58:11.422 --> 00:58:15.125 I can't even look at you, at your body. 00:58:15.126 --> 00:58:17.460 I mean, I hate that... 00:58:17.461 --> 00:58:21.396 that hole, that scar. 00:58:23.133 --> 00:58:27.068 I'm sorry. I just... 00:58:36.946 --> 00:58:39.414 Paul... 00:59:27.063 --> 00:59:28.598 Knudson's two-hit theory? 00:59:28.599 --> 00:59:31.468 Normal cells have two undamaged chromosomes... 00:59:31.469 --> 00:59:33.069 - ...one from the mom... - And one from the dad. 00:59:33.070 --> 00:59:36.973 Right. Now, let's say there is some sort of hereditary predisposition to cancer. 00:59:36.974 --> 00:59:40.975 All that means is that one of the genes is damaged. 00:59:42.011 --> 00:59:44.681 I still haven't heard from Dr. King. 00:59:44.682 --> 00:59:48.051 I don't think you're the only person to write to her, Annie. 00:59:48.052 --> 00:59:50.819 In the last five years, the Broad Institute, the Genome Institute... 00:59:50.820 --> 00:59:54.923 at Washington University, and the Baylor College of Medicine... 01:00:03.166 --> 01:00:06.469 And I would go through life with this one bad gene, 01:00:06.470 --> 01:00:10.039 and everything's still okay, because the other gene is fine, right? 01:00:10.040 --> 01:00:12.208 And then one of these factors comes along, like those... 01:00:12.209 --> 01:00:15.678 All that would mean is that they would have to damage the other gene? 01:00:15.679 --> 01:00:18.581 Right. And then the cell is damaged enough that it can mutate. 01:00:18.582 --> 01:00:23.286 - Which could be cancer. - Could be. Can be. It's, uh... 01:00:38.234 --> 01:00:40.936 It's all too much. 01:01:05.962 --> 01:01:08.997 Is this a doctorly hug? 01:01:14.003 --> 01:01:16.438 I should... I should leave. 01:01:18.274 --> 01:01:21.309 He was a lovely man and a friend. 01:01:21.479 --> 01:01:26.649 But love is like DNA. We can't know its predispositions. 01:01:27.651 --> 01:01:31.654 It wasn't to be. For me, anyway. 01:01:52.809 --> 01:01:55.111 - Where's Dad? - I don't know, sweetie. 01:01:55.112 --> 01:01:57.313 Maybe he went to work early. 01:01:57.314 --> 01:02:01.049 - Where's Dad? - Come on. Eat your oatmeal. 01:02:16.466 --> 01:02:18.001 Not this. Please. Come on. 01:02:18.002 --> 01:02:20.336 I'm not gonna eat till you tell me where Dad is. 01:02:20.337 --> 01:02:23.206 - Eat your oatmeal. - Where's Dad? 01:02:23.207 --> 01:02:26.075 - Eat your oatmeal. - I don't want to. 01:02:26.076 --> 01:02:29.311 I said eat your goddamn oatmeal now! 01:02:32.715 --> 01:02:37.486 Oh, God. William! Honey, I'm sorry. 01:02:45.862 --> 01:02:47.497 William! 01:02:52.502 --> 01:02:57.672 William, no. These are Mommy's things. William, no. Please don't. 01:03:01.577 --> 01:03:04.814 Oh, sweetie, I'm sorry. 01:03:04.815 --> 01:03:06.849 Come here. Come here. 01:03:06.850 --> 01:03:10.019 Sweetie, come on. Come on. 01:03:10.020 --> 01:03:12.088 Come on. 01:03:12.089 --> 01:03:15.258 Hey, come on. I'm sorry. 01:03:15.259 --> 01:03:19.059 Hey, sweetie, come on. Come here. 01:03:23.099 --> 01:03:27.270 God, I'm sorry. I will never, ever talk to you like that again. 01:03:27.271 --> 01:03:29.539 - Okay? I'm so sorry. - I'm sorry. 01:03:29.540 --> 01:03:34.109 Hey, you don't need to be sorry. They're Mommy's silly things. 01:03:42.885 --> 01:03:46.055 Louise? Louise! 01:03:46.056 --> 01:03:48.090 Sweetie? 01:03:50.927 --> 01:03:52.795 Louise? 01:03:57.900 --> 01:04:00.135 Stop! 01:04:03.106 --> 01:04:05.674 Oh, shit. 01:05:00.296 --> 01:05:02.665 - Divorced? - Yes, sweetie. 01:05:02.666 --> 01:05:04.667 Mommy and Daddy are gonna live in different houses, 01:05:04.668 --> 01:05:06.936 but that doesn't mean we don't love you very, very much. 01:05:06.937 --> 01:05:09.172 This way, you'll have two houses. 01:05:09.173 --> 01:05:12.708 I don't want two houses. I want us all together in one house. 01:05:12.709 --> 01:05:16.012 - So does Dad. - Please, Paul, don't do that. 01:05:16.013 --> 01:05:17.914 What? I'm telling the truth. 01:05:17.915 --> 01:05:21.883 - I knew this was your fault. - No, it's not my fault, honey. Paul? 01:05:21.884 --> 01:05:25.521 Maybe if you didn't spend all your time on this DNA shit. 01:05:25.522 --> 01:05:30.082 - At least there's a reason for that. - Reason? Really? What reason? 01:05:30.083 --> 01:05:32.236 - Tell me the reason. - Because I have to know. 01:05:32.237 --> 01:05:34.289 - Are you fucking joking? - Language. 01:05:34.290 --> 01:05:36.666 You have a high school education, Annie. 01:05:36.667 --> 01:05:39.035 You don't know anything. You're not gonna find out anything. 01:05:39.036 --> 01:05:41.637 - Is that why you won't touch me? - Oh, here we go. 01:05:41.638 --> 01:05:46.842 Oh, so you can say... you can say that. But I fucking can't say "fucking"? 01:05:47.244 --> 01:05:51.364 Do you wanna tell him the real truth? Tell him about Louise? 01:05:51.690 --> 01:05:54.501 - Oh, my God. - What about Aunt Louise? 01:05:54.502 --> 01:05:58.595 Nothing, William. It's nothing. 01:06:01.490 --> 01:06:03.826 Tell you what, Annie. 01:06:04.228 --> 01:06:07.794 I am sorry. I tried. 01:06:07.896 --> 01:06:11.934 - I tried. I just couldn't. - Get out. 01:06:11.935 --> 01:06:14.702 - What? - Get out. 01:06:20.142 --> 01:06:23.145 I'll tell you what, Annie. 01:06:23.247 --> 01:06:26.748 At least she was there for me. 01:06:39.896 --> 01:06:41.898 I'm so sorry. 01:06:43.000 --> 01:06:45.368 What's going on? 01:06:45.369 --> 01:06:47.970 - Come on. - Just listen. 01:06:47.971 --> 01:06:50.973 These four women have breast cancer. 01:06:50.974 --> 01:06:55.544 What they've found are certain, let's call them odd proteins, 01:06:55.545 --> 01:07:00.282 that have unique configurations in the parent gene. Let's say these are them. 01:07:00.584 --> 01:07:05.254 We can identify them by their unique, say, shape. 01:07:06.056 --> 01:07:10.026 Now, each parent donates a gene to the child, 01:07:10.027 --> 01:07:12.628 and the genes get all mixed up, right? 01:07:12.629 --> 01:07:16.565 But look. It's not completely arbitrary. 01:07:16.566 --> 01:07:18.567 - We have news. - Genetic markers. 01:07:18.568 --> 01:07:23.103 - We can track them through their families. - And what we can call linkage. 01:07:24.173 --> 01:07:26.442 Do you see it? 01:07:26.443 --> 01:07:29.211 We now know that even though 01:07:29.212 --> 01:07:34.583 our genes get all mixed up when we're conceived, certain markers remain. 01:07:34.584 --> 01:07:36.652 - Markers? - Genetic markers. 01:07:36.653 --> 01:07:42.124 We can track them through the families. It's like a signpost on a highway. 01:07:42.125 --> 01:07:44.193 Say you have two stretches of road in the desert. 01:07:44.194 --> 01:07:45.795 - And they look exactly the same. - Right. 01:07:45.796 --> 01:07:49.131 But if you pass signposts, you can measure the intervals. 01:07:49.132 --> 01:07:50.833 And you can identify the different stretches of road. 01:07:50.834 --> 01:07:52.702 Even if they look exactly the same. 01:07:52.703 --> 01:07:55.471 And if those markers are next to something, like the breast cancer gene, 01:07:55.472 --> 01:07:58.774 - it can be identified. - We now know that even though 01:07:58.775 --> 01:08:04.680 our genes get all mixed up when we're conceived, certain markers remain. 01:08:05.582 --> 01:08:10.451 If we can find these markers, we're in striking distance of finding our gene. 01:08:23.967 --> 01:08:28.938 Kim kept encouraging me to go out. I think she wanted me to meet someone. 01:08:29.840 --> 01:08:32.475 Is your wife gonna join you this evening? 01:08:32.476 --> 01:08:35.411 I, um... 01:08:35.412 --> 01:08:39.950 - I am no longer married. - Mm-hmm. 01:08:41.852 --> 01:08:44.186 - So is your girlfriend coming later? - Really? 01:08:44.187 --> 01:08:48.824 - That's really none of your business. - Mm-hmm. 01:08:49.226 --> 01:08:51.327 Hey, is your daddy's girlfriend coming tonight? 01:08:51.328 --> 01:08:53.929 Dad doesn't have a girlfriend. 01:08:54.331 --> 01:08:58.234 - At a peewee hockey game, I met Marshall. - I'm sorry about my friend. 01:08:58.235 --> 01:09:00.036 I'm Marshall. 01:09:00.037 --> 01:09:01.370 - I'm Annie. - Hi. 01:09:01.371 --> 01:09:05.507 Only a Canadian girl meets a man at a peewee hockey game. 01:09:26.495 --> 01:09:29.999 Christmastime is almost here again 01:09:30.000 --> 01:09:33.702 People come from far and near again 01:09:33.703 --> 01:09:39.607 Isn't Christmastime a wonderful thing? 01:09:40.877 --> 01:09:44.580 Deck the halls and hang the mistletoe 01:09:44.581 --> 01:09:47.950 Kiss the ones you love and let 'em know 01:09:47.951 --> 01:09:52.680 Isn't Christmastime a wonderful thing? 01:09:55.057 --> 01:09:57.759 - Dad! - Hiya, sport! 01:10:01.530 --> 01:10:03.331 Hi, Paul. 01:10:12.074 --> 01:10:13.542 Hi. 01:10:13.543 --> 01:10:14.877 Yeah. 01:10:14.878 --> 01:10:17.179 - How are you? - Hi. 01:10:17.180 --> 01:10:19.682 You look good. You look great. 01:10:19.683 --> 01:10:22.751 Really, really happy. 01:10:23.653 --> 01:10:25.346 You okay? 01:10:25.347 --> 01:10:28.324 Yeah. Doing all right. 01:10:28.325 --> 01:10:31.492 Been a little sick. 01:10:32.528 --> 01:10:35.831 So, um, Marshall. 01:10:35.832 --> 01:10:37.900 He's a good man. 01:10:37.901 --> 01:10:40.703 - Yeah, he is. - Yeah. 01:10:40.704 --> 01:10:42.905 - You okay? - Okay. 01:10:42.906 --> 01:10:46.874 Um, I'm gonna go get some... some food. 01:10:47.910 --> 01:10:50.011 Come on, sport. 01:11:00.456 --> 01:11:02.591 Tom, you open up the betting. 01:11:02.592 --> 01:11:05.693 All right. Okay. 01:11:09.865 --> 01:11:13.801 Another bad hand, but what the heck? 01:11:16.172 --> 01:11:19.841 Fold. 01:11:23.345 --> 01:11:25.681 Annie. Annie. 01:11:25.682 --> 01:11:27.283 - Hey! - I wanted to... 01:11:27.284 --> 01:11:30.485 I'm smiling at you, but you can fuck off. 01:11:40.629 --> 01:11:42.565 This is fun. 01:11:42.566 --> 01:11:44.599 Yeah. 01:11:47.736 --> 01:11:50.938 - Good to see you, guys. - You too, man. 01:11:59.448 --> 01:12:02.651 - I'd love to hear that conversation. - Oh, no. 01:12:02.652 --> 01:12:07.055 - You invited them. - Yeah, but I didn't think they'd interact. 01:12:08.357 --> 01:12:10.992 - Merry Christmas. - Merry Christmas. 01:12:14.897 --> 01:12:17.233 Well, I'll be back. 01:12:17.234 --> 01:12:20.201 Great. Okay. Yeah. We're... 01:12:24.573 --> 01:12:27.276 Is it weird? Did it get weird? 01:12:27.277 --> 01:12:30.445 - Merry Christmas, Marshall. - Merry Christmas. 01:12:32.681 --> 01:12:34.816 Here's to her. 01:12:35.318 --> 01:12:37.653 To Annie. 01:12:44.460 --> 01:12:46.962 Marshall. 01:12:47.864 --> 01:12:49.732 Marshall? 01:12:49.733 --> 01:12:52.000 I'm up here, hon. 01:12:52.102 --> 01:12:54.837 Marshall? 01:12:54.838 --> 01:12:58.407 I'm in here. I, uh... 01:12:59.309 --> 01:13:02.578 I found the key. I thought I'd... 01:13:02.579 --> 01:13:06.181 clean out this room. We could use it as a guest room or, uh... 01:13:06.182 --> 01:13:08.751 - No, you didn't. - ...a study. 01:13:08.752 --> 01:13:11.453 Keep your helixes in here. 01:13:11.454 --> 01:13:16.356 - Did Mommy wake him up? - Yes, she did. 01:13:16.425 --> 01:13:19.427 No. You let him out. 01:13:20.863 --> 01:13:23.132 You let him out. 01:13:23.133 --> 01:13:28.270 - Who? - You... There's no one here. 01:13:28.271 --> 01:13:30.906 - It's just a room. - You can't go in that room. 01:13:30.907 --> 01:13:34.075 - You let him out. - Honey, no. 01:13:34.277 --> 01:13:36.711 It's just a... 01:13:44.853 --> 01:13:48.261 Seriously, I wouldn't believe this either, except it happened. 01:13:48.262 --> 01:13:51.959 Louise called me and told me that Paul was ill. 01:13:56.032 --> 01:13:58.666 Hey, um... 01:14:00.469 --> 01:14:04.571 Doctor says colorectal cancer. 01:14:04.773 --> 01:14:07.742 Hey, um... 01:14:09.578 --> 01:14:14.617 I was looking through these, and, uh... 01:14:16.319 --> 01:14:19.187 thought you might wanna see them. 01:14:28.263 --> 01:14:31.265 You gonna be okay with William? 01:14:33.068 --> 01:14:37.305 - By yourself, I mean? - Paul... 01:14:59.929 --> 01:15:03.565 Imagine me and you 01:15:03.967 --> 01:15:06.168 I do 01:15:07.070 --> 01:15:10.272 - Think about you day and night - Day and night 01:15:10.273 --> 01:15:12.408 It's only right 01:15:12.409 --> 01:15:16.545 To think about the girl you love 01:15:16.546 --> 01:15:23.083 and hold her tight So happy together 01:15:28.691 --> 01:15:31.625 What did you ever see in me? 01:15:33.962 --> 01:15:37.800 I loved the careless, 01:15:37.801 --> 01:15:41.469 boundless, wildness of you. 01:15:42.504 --> 01:15:45.306 Then what happened? 01:15:47.042 --> 01:15:50.177 You were boundless and careless. 01:16:00.522 --> 01:16:01.990 Paul. 01:16:01.991 --> 01:16:05.060 Hey, listen. 01:16:05.061 --> 01:16:07.696 I want you to do something for me. 01:16:07.697 --> 01:16:12.101 - What is that? - I want you to believe. 01:16:13.403 --> 01:16:15.771 Believe in what? 01:16:15.772 --> 01:16:18.740 Believe in anything. 01:16:19.142 --> 01:16:21.976 Come on, Annie. 01:16:22.178 --> 01:16:25.113 Come on. It worked for me. 01:16:26.015 --> 01:16:30.083 Uh, no offense, but... 01:16:30.853 --> 01:16:35.891 believing that there's some miracle cure out there 01:16:35.892 --> 01:16:39.193 that no one knows about, that's... 01:16:39.295 --> 01:16:42.529 You gotta believe in something. 01:16:43.632 --> 01:16:45.501 I do. 01:16:45.502 --> 01:16:48.769 I do believe in something, Annie. 01:16:57.246 --> 01:17:00.614 I believe in cancer. 01:17:02.551 --> 01:17:06.320 And you know what else I believe in, Annie? 01:17:07.556 --> 01:17:13.418 I believe... that I am going to die. 01:17:40.956 --> 01:17:42.923 Okay. 01:17:50.566 --> 01:17:54.034 I'm gonna go now, okay, sweetie? 01:18:03.812 --> 01:18:07.549 Just like he said he would, Paul died. 01:18:07.550 --> 01:18:10.352 I realized then that was the difference, 01:18:10.353 --> 01:18:14.923 and that was the answer to the question everyone was always asking me. 01:18:14.924 --> 01:18:20.162 Paul didn't believe in anything in the end. I did. 01:18:20.163 --> 01:18:23.198 I believed in my genes and chromosomes. 01:18:23.199 --> 01:18:27.970 I believed in my helix, and I believed in predispositions. 01:18:27.971 --> 01:18:31.306 Faith. It may not seem like faith, 01:18:31.307 --> 01:18:35.778 not as you might think it, but it is. 01:18:35.779 --> 01:18:40.148 And maybe those who say faith sustains us are right. 01:18:40.149 --> 01:18:43.518 And maybe it doesn't matter what we have faith in 01:18:43.519 --> 01:18:47.088 as long as it's faith in something, 01:18:47.089 --> 01:18:49.790 like the future. 01:18:52.427 --> 01:18:56.699 My brother died of lung cancer, uh, and colon cancer. 01:18:56.700 --> 01:19:00.602 I had never seen cancer until I saw colon cancer, okay? 01:19:00.603 --> 01:19:04.239 Blood coming out of everywhere, and it was just... 01:19:04.240 --> 01:19:08.343 I don't know how you can go on. I don't think I could. 01:19:08.344 --> 01:19:12.381 It's agony. It's the shit I deal with. 01:19:12.382 --> 01:19:15.315 I know what it's like. 01:19:39.241 --> 01:19:43.878 Yeah. I'm telling you, it was the same guy. 01:19:44.380 --> 01:19:47.814 Either one or both of the parents were... 01:19:48.383 --> 01:19:52.586 - Or they both had the receptive... - One of the parents had some... 01:19:55.357 --> 01:19:59.059 Yeah. It seemed random. 01:20:07.169 --> 01:20:09.537 You okay, Annie? 01:20:15.645 --> 01:20:19.414 I'm afraid I don't have good news for you. 01:20:19.415 --> 01:20:22.651 We found malignant tumors on both your ovaries, 01:20:22.652 --> 01:20:27.355 with involvement of the fallopian tubes and elsewhere in your abdomen. 01:20:27.457 --> 01:20:30.158 Do you understand what I just said? 01:20:30.159 --> 01:20:34.830 Now, while you do have an advanced form of ovarian cancer, 01:20:34.831 --> 01:20:37.666 we removed everything that we found. 01:20:37.667 --> 01:20:43.270 Anything left is potentially curable with chemotherapy. 01:20:45.440 --> 01:20:47.742 Advanced? 01:20:47.944 --> 01:20:50.211 Stage three. 01:20:50.313 --> 01:20:53.215 You have a long, hard fight ahead of you. 01:20:53.216 --> 01:20:57.519 - I'm 37. - Oh, that's very young. 01:20:58.221 --> 01:21:01.923 You rest, and we'll talk later, all right? 01:21:11.066 --> 01:21:14.703 All right. I've reviewed your pathology reports, 01:21:14.704 --> 01:21:17.973 and it's good you had the surgery. 01:21:17.974 --> 01:21:23.711 Please, Doctor. You know I prefer bad news. Cheers me up. 01:21:23.813 --> 01:21:27.449 With what we're seeing on your path reports, 01:21:27.450 --> 01:21:31.520 I have to tell you, this type of cancer 01:21:31.521 --> 01:21:36.625 responds best to a combination of chemotherapy drugs. 01:21:36.626 --> 01:21:41.830 We'd like you to receive cisplatin and cyclophosphamide. 01:21:41.831 --> 01:21:45.166 Maybe ten or twelve treatments. 01:21:45.568 --> 01:21:47.402 How long? 01:21:47.403 --> 01:21:51.038 Altogether, a year or so. 01:21:56.278 --> 01:22:00.481 - I've been here before. - I know you have. 01:22:02.584 --> 01:22:06.919 So what do you say? Hmm? 01:22:20.569 --> 01:22:23.738 Damn, you're hot. 01:22:41.489 --> 01:22:43.557 I need some water. 01:22:43.659 --> 01:22:47.662 One breast, no hair. 01:22:47.663 --> 01:22:51.631 They all want you, but they can't have you. 01:22:56.004 --> 01:22:58.306 Just hold on a minute. 01:22:59.008 --> 01:23:00.941 Sorry. 01:23:09.885 --> 01:23:14.723 I'm gonna be sick. I'm gonna be sick. I'm gonna be sick. 01:23:15.825 --> 01:23:17.624 Oh! 01:23:22.264 --> 01:23:25.400 You are so hot, baby. 01:23:25.401 --> 01:23:29.070 One breast, no hair. 01:23:29.071 --> 01:23:33.108 What's weird is that you want your mom. I just want my mommy. 01:23:33.109 --> 01:23:35.776 I just want my mommy. 01:23:37.679 --> 01:23:40.382 - You need the nurse? - I'm in too much pain. 01:23:40.383 --> 01:23:44.386 - You need the nurse? - I want... I'm in too much pain. 01:23:44.387 --> 01:23:47.455 Okay. Are you comfortable? 01:23:47.456 --> 01:23:50.692 No. I'm hot. Let me take... 01:23:50.693 --> 01:23:53.128 I'll take 'em off. 01:23:53.830 --> 01:23:59.233 They all want you, but they can't have you. 01:24:18.320 --> 01:24:21.421 - It hurts me. - I know, sweetie. 01:24:23.491 --> 01:24:25.993 It really hurts. 01:24:27.562 --> 01:24:29.964 No. 01:24:30.366 --> 01:24:32.866 No, they can't. 01:25:07.902 --> 01:25:10.704 Dr. King, are you all right? 01:25:16.477 --> 01:25:19.014 - Dr. King, are you... - Maybe there's something acting 01:25:19.015 --> 01:25:24.885 on these genes. Maybe it's not happening independently or spontaneously. 01:25:28.223 --> 01:25:31.126 Controlling genes. 01:25:31.127 --> 01:25:34.795 Squeeze one more time for me. 01:25:34.897 --> 01:25:36.931 Okay. Okay. 01:25:36.932 --> 01:25:40.702 Well, let's try the other arm, hmm? 01:25:40.703 --> 01:25:42.470 Sorry, Annie. 01:25:42.471 --> 01:25:46.474 This happens when you've had too much chemo. 01:25:46.475 --> 01:25:50.545 The veins get scarred and are hard to use. 01:25:50.546 --> 01:25:53.248 Like a junkie. 01:25:54.150 --> 01:25:58.086 Well, next time, I'll put in a portacath. 01:25:58.087 --> 01:26:02.390 - That'll last several sessions. - Okay. 01:26:02.391 --> 01:26:04.993 Yeah? I think we've found one. 01:26:04.994 --> 01:26:07.427 - Yay. - Right there. 01:26:09.931 --> 01:26:12.434 - Hey. - Wow. 01:26:12.435 --> 01:26:16.671 - Cancer haute couture. - Ta-da! 01:26:17.573 --> 01:26:22.076 - Not a good look, then? - It's... a look. 01:26:24.746 --> 01:26:28.815 Thanks, Brian. Thank you. 01:26:31.086 --> 01:26:34.254 - They're beautiful. - You are. 01:26:36.891 --> 01:26:39.461 - What's going on? - Excellent question. 01:26:39.462 --> 01:26:42.931 Let me show you what's going on. Maybe you can figure it out for us. 01:26:42.932 --> 01:26:45.066 Look around you. What do you see? 01:26:45.067 --> 01:26:46.568 A lot of paper. 01:26:46.569 --> 01:26:48.770 Each paper represents parts of chromosomes 01:26:48.771 --> 01:26:51.740 that we suspect may be active in the cancer of our test patients. 01:26:51.741 --> 01:26:55.310 In other words, these areas are variants, mutations in the DNA. 01:26:55.311 --> 01:26:58.279 - Our 350... all cancer sufferers. - Why are there so many? 01:26:58.280 --> 01:27:00.582 Because it represents many generations. 01:27:00.583 --> 01:27:03.318 - See these red dots? - Yeah. 01:27:03.319 --> 01:27:07.155 Wherever they appear is an indication of a mutation. 01:27:07.156 --> 01:27:10.759 Black lines... morbidity, death. 01:27:10.760 --> 01:27:13.428 So there's a lot of mutation? 01:27:13.429 --> 01:27:16.231 Yeah. Everyone's DNA has a certain amount of variation. 01:27:16.232 --> 01:27:19.968 What we're looking for is a mutation the same place on the same chromosome. 01:27:19.969 --> 01:27:22.237 Mary-Claire, if we're looking for patients who have... 01:27:22.238 --> 01:27:24.439 - a predisposition to breast cancer... - Yes. 01:27:24.440 --> 01:27:26.941 That would suggest that they were born with a mutated gene. 01:27:26.942 --> 01:27:29.544 - Yes. - But most cancers occur later in life, 01:27:29.545 --> 01:27:33.515 - when the telomeres are reduced in size. - Right. 01:27:33.516 --> 01:27:36.217 So if we concentrate on women who have early-onset cancer, 01:27:36.218 --> 01:27:39.921 we'd be much more likely to find women who have a predisposition. 01:27:39.922 --> 01:27:42.724 We were presuming that all breast cancers were caused by the same thing. 01:27:42.725 --> 01:27:45.121 Yes, but if they have similar tumors but different causes... 01:27:45.122 --> 01:27:48.829 And we just look at women with early-onset cancer... 01:27:50.932 --> 01:27:52.900 Do it. 01:27:55.403 --> 01:27:57.205 Average age, 28. 01:27:57.206 --> 01:28:00.207 - 40. - 35. 01:28:04.579 --> 01:28:06.880 Where is it? 01:28:11.920 --> 01:28:13.955 It's here. 01:28:14.857 --> 01:28:17.025 And here. 01:28:18.327 --> 01:28:20.595 And here. 01:28:21.297 --> 01:28:23.664 And here. 01:28:23.866 --> 01:28:25.999 And here. 01:28:31.639 --> 01:28:34.074 We found our gene. 01:28:36.578 --> 01:28:39.346 That's Mary-Claire King. 01:28:39.448 --> 01:28:43.885 There's a link. There's a link. You understand what I'm saying? 01:28:43.886 --> 01:28:49.257 There's a genetic link between mothers and daughters 01:28:49.258 --> 01:28:53.360 and sisters who have had breast cancer. 01:28:53.562 --> 01:28:57.664 See, there's a predisposition. A kind of mutation. 01:28:57.866 --> 01:29:00.535 There's a link. 01:29:01.437 --> 01:29:03.537 You were right. 01:29:07.709 --> 01:29:10.077 Excuse me. 01:30:58.820 --> 01:31:03.458 Hello. Hi. Hey, I heard the good news. 01:31:03.459 --> 01:31:07.729 - Allen, she's in Cincinnati. - Cincinnati? 01:31:07.730 --> 01:31:09.797 They could hardly believe it. 01:31:09.798 --> 01:31:12.834 Yeah, well, they believe her now, huh? 01:31:12.835 --> 01:31:16.435 They do. Anybody who ever doubted us. Well, her. 01:31:16.436 --> 01:31:18.177 - She did it. - A single gene. 01:31:18.178 --> 01:31:21.140 - Pretty much. - Incredible. 01:31:21.466 --> 01:31:22.877 So, what now? 01:31:22.878 --> 01:31:24.445 Oh, there's still lots to be done. 01:31:24.446 --> 01:31:27.448 We have to pinpoint the precise gene and sequence it. 01:31:27.449 --> 01:31:30.350 Yeah, well, that's where the money is. 01:31:32.587 --> 01:31:35.023 - The money? - Yeah. Lots and lots and lots of money. 01:31:35.024 --> 01:31:38.908 You sequence the gene, and then you patent it. It's yours. 01:31:38.909 --> 01:31:44.806 Do me a favor, will you? Say good-bye to Dr. King for me. 01:31:44.933 --> 01:31:46.935 And, uh... 01:31:48.837 --> 01:31:52.806 you know, congrats and all that. She is something. 01:32:03.884 --> 01:32:05.686 - Excuse me, Dr. King? - I'm sorry. 01:32:05.687 --> 01:32:08.189 I don't have any more time. I'm already late for my plane. 01:32:08.190 --> 01:32:11.825 - My name's Annie Parker. - Thanks. 01:32:13.928 --> 01:32:16.097 Oh. 01:32:16.999 --> 01:32:19.133 I read your letters. 01:32:19.134 --> 01:32:21.302 I heard you were in town. 01:32:21.303 --> 01:32:25.406 I tried to catch your lecture, but the traffic was horrible. 01:32:25.407 --> 01:32:28.643 - I'm sorry. - It's okay. It was a bit dry. 01:32:28.644 --> 01:32:31.379 My jokes didn't play very well. 01:32:32.181 --> 01:32:34.948 - So I... - I've wanted to meet you. 01:32:36.551 --> 01:32:39.454 I wanted to meet you, too. 01:32:39.455 --> 01:32:44.290 So I heard they patented our gene... your gene. 01:32:44.759 --> 01:32:47.295 That's right. They have. 01:32:47.296 --> 01:32:50.076 So does that mean we get a discount on it in the future if we need it, 01:32:50.077 --> 01:32:54.944 - like a Sears card? - It's not a cure, of course. 01:32:55.571 --> 01:33:00.308 No. Yeah. I heard, but it's a start. 01:33:00.309 --> 01:33:02.810 That's right. It's a start. 01:33:03.712 --> 01:33:06.681 - That's a pretty necklace. - Thank you. 01:33:06.682 --> 01:33:10.850 It was my mom's. I had it restrung recently. 01:33:11.686 --> 01:33:13.054 - You know, she... - Hey, I'm sorry. 01:33:13.055 --> 01:33:18.625 I really do have to go. I hope we can speak again. All the best. 01:33:38.212 --> 01:33:43.251 You are a remarkable woman, Anne Parker. 01:33:44.353 --> 01:33:48.589 I'm sorry... so sorry I couldn't do more. 01:33:49.191 --> 01:33:54.093 You did so much. So very much. 01:34:25.393 --> 01:34:30.264 Oh, the gentlemen are talking 01:34:30.265 --> 01:34:35.136 And the midnight moon is on the riverside 01:34:35.137 --> 01:34:40.408 They're drinking up and walking 01:34:40.409 --> 01:34:45.780 And it is time for me to slide 01:34:45.781 --> 01:34:50.084 I live in another world 01:34:50.085 --> 01:34:56.190 Where life and death are memorized 01:34:56.191 --> 01:35:01.195 Where the earth is strung with lover's pearls 01:35:01.196 --> 01:35:07.633 And all I see are dark eyes 01:35:26.253 --> 01:35:30.191 I can't control 01:35:30.192 --> 01:35:34.628 What life is now 01:35:34.629 --> 01:35:41.267 What will roll over me 01:35:42.403 --> 01:35:46.374 It's not freedom 01:35:46.375 --> 01:35:49.910 But it set you free 01:35:49.911 --> 01:35:56.617 So see yourself as free 01:35:57.219 --> 01:36:04.957 As I'm falling from your reach 01:36:06.027 --> 01:36:14.001 Don't forget Don't regret 01:36:14.002 --> 01:36:21.876 Don't dwell on the past 01:36:21.877 --> 01:36:29.583 Nothing left Nothing sacred 01:36:29.584 --> 01:36:33.120 Nothing pure 01:36:33.121 --> 01:36:36.924 is ever gonna last 01:36:36.925 --> 01:36:40.528 You should turn away from me 01:36:40.529 --> 01:36:44.330 As I drift away from you 01:36:46.901 --> 01:36:50.938 If time has spent 01:36:50.939 --> 01:36:55.176 and time has come 01:36:55.177 --> 01:37:02.884 to let me go and you to run 01:37:02.885 --> 01:37:06.187 Then let me leave 01:37:06.188 --> 01:37:10.689 and let me go 01:37:10.792 --> 01:37:17.698 To see yourself as free 01:37:17.699 --> 01:37:25.471 As I'm falling from your reach 01:37:26.574 --> 01:37:30.210 Don't forget 01:37:30.512 --> 01:37:34.181 Don't regret 01:37:34.483 --> 01:37:42.356 Don't dwell On the past 01:37:42.357 --> 01:37:50.297 Nothing left Nothing sacred 01:37:50.298 --> 01:37:53.701 Nothing pure 01:37:53.702 --> 01:37:57.671 is ever gonna last 01:37:57.672 --> 01:38:01.242 You should turn away from me 01:38:01.243 --> 01:38:04.244 as I drift away from you 01:38:41.515 --> 01:38:44.918 Don't forget 01:38:45.320 --> 01:38:48.855 Don't regret 01:38:49.257 --> 01:38:57.064 Don't you dwell on the past 01:38:57.065 --> 01:39:04.972 Nothing left Nothing sacred 01:39:04.973 --> 01:39:08.376 Nothing pure 01:39:08.377 --> 01:39:12.379 is ever gonna last 01:39:12.380 --> 01:39:15.916 You should turn away from me 01:39:15.917 --> 01:39:19.586 as I drift away from you